I've banked with TD all my life, set up my LOC last week with RBC. RBC had a tonne of incentives for my med school, beyond those on their website, so ask! (TD told me their interest rate was prime+1 and weren't willing to change it to be competitive, happened at two branches in different cities so I went elsewhere. Oh also they weren't willing to bump me up to an unlimited transaction account with the fees waived.)
It's not/hasn't been a pain as of yet, just had to set up an account with the other institution.