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Which LOR scenario would be better?

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Ok so i was wondering which of the two referees would be better:


A. Physiology (300 level) course: got 90% in course but dont know the prof at all so he would have to totally base his letter on my grade and perhaps my statement/resume.


B. Organic Chemistry (200 level): low A (80%) in course but prof knows me as i stayed in help sessions,answered questions during class AND my grade improved from a B to an A and my prof knows and complemented me on this improvement.


While B seems an ok option, what would one choose if this was their only academic LOR (rest being research LORs)?



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