Probably want to talk to an accountant about this. When you're into six figures, there might be ways to structure it more advantageously. Or at least get a small piece of infrastructure named after yourself by your appreciative recipient (if you're into that).
But I don't know, mostly because I don't have a hundred large burning a hole in my pocket every year. You might not, either.
While $350k per year sounds like an outrageous amount of money, by the time you account for overhead, taxes, mortgage, debt repayment, insurance, retirement savings etc it will likely be a lot less and you might not have a spare $8300 per month to donate to charity. More power to you if you do, but make sure you've done the math.